TRT › Head-to-head comparison
DudeMeds vs DirectMeds
True annual cost, labs inclusion, delivery methods, and verified reviews compared. Updated March 2026.
★
Our pick: DudeMeds — 8.8/10 vs 8.8/10, $1,264/yr cheaper
★ Our Pick
DudeMeds
$77/mo — FDA-approved commercial testosterone, SubQ injections
8.8/10
Monthly
$77/mo
True Annual
$1,124/yr
Labs
✗ Extra
States
Most states
Pros
✓Very competitive pricing
✓FDA-approved commercial testosterone
✓Painless SubQ injections
Cons
✗Labs not included
✗Not all states
VS
DirectMeds
Compounded GLP-1 from $199/mo — semaglutide and tirzepatide, labs optional
8.8/10
Monthly
$199/mo
True Annual
$2,388/yr
Labs
✗ Extra
States
All 50
Pros
✓Fast approval process — under 24 hours
✓Compounded sema and tirzepatide available
✓Free shipping on all orders
Cons
✗Labs not included
✗Newer provider
Side-by-side comparison
| Feature | DudeMeds | DirectMeds |
|---|---|---|
| Monthly price | $77/mo | $199/mo |
| True annual cost | $1,124/yr | $2,388/yr |
| Labs included | ✗ No | ✗ No |
| Delivery options | injection, oral | injection |
| Editorial score | 8.8/10 | 8.8/10 |
| Trustpilot | 4.3★ | 4.5★ |
| State availability | Most US states | All 50 states |
Our verdict
DudeMeds (8.8/10) is our pick over DirectMeds (8.8/10) for most patients. At $1,124/yr vs $2,388/yr, DudeMeds saves you $1,264 per year.
DirectMeds may be a better fit if you prefer DirectMeds's specific protocol approach. Both clinics require a prescription and blood work before starting treatment.
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