Semaglutide is a single molecule. It does not change between providers. But the price you pay for a monthly supply of compounded semaglutide through a telehealth platform ranges from $99 to $400 per month — a 4x spread for the identical active ingredient.

We went through pricing from 17 platforms and the differences are worth understanding before you commit to any program.

Why the price varies so much

Several factors drive the spread:

Dose. Starter doses (0.25mg/week) cost less than maintenance doses (1–2.4mg/week). Advertised pricing almost always reflects starter dose. Your actual ongoing cost at therapeutic dose is typically 40–100% higher.

Pharmacy markup. 503A compounding pharmacies set their own prices. A platform that uses a premium pharmacy will charge more.

Program structure. Some platforms bundle the consultation, lab work, ongoing messaging, and medication into one price. Others charge separately for each.

API quality. The base form of semaglutide costs more than salt forms (semaglutide sodium or semaglutide acetate). Platforms using higher-quality API pass that cost along.

What the actual ranges look like

Starter dose programs (0.25–0.5mg/week): $99–$199/month Mid-dose programs (0.5–1mg/week): $150–$299/month Maintenance dose programs (1–2.4mg/week): $199–$400/month

These numbers reflect medication cost only. Add the consultation fee (typically $49–$99 one-time), lab work if not included ($75–$200/draw), and any shipping fees.

The programs ClinicLayer tracks and their pricing

We verify pricing daily across all platforms in our database. The lowest true all-in monthly cost we have confirmed for compounded semaglutide at a maintenance dose is Zealthy at $99/month (starter) scaling to approximately $200/month at therapeutic dose. DirectMeds runs $199–$299/month depending on dose tier. CareBare and Enhance MD are similar.

The honest take on price shopping GLP-1 programs

Cheaper is not always better and more expensive is not always worth it. The variables that actually matter: is the pharmacy 503A-licensed and inspected, what does ongoing clinical support look like, and what happens when you need a dose adjustment. Those factors are worth more than a $50/month difference in price.