GLP-1 / Weight Loss › Head-to-head comparison
Sesame Care vs DirectMeds
True annual cost, labs inclusion, delivery methods, and verified reviews compared. Updated March 2026.
★
Our pick: DirectMeds — 8.8/10 vs 8.3/10, higher rated
Sesame Care
Direct-to-patient marketplace — GLP-1, ED, HRT, mental health from $16/appt
8.3/10
Monthly
$16/mo
True Annual
$192/yr
Labs
✗ Extra
States
All 50
Pros
✓Available in all 50 states
✓No insurance required — transparent cash pricing
✓Same-day telehealth or in-person appointments
Cons
✗Marketplace model — quality varies by provider
✗Lower recurring revenue than subscription clinics
VS
★ Our Pick
DirectMeds
Compounded GLP-1 from $199/mo — semaglutide and tirzepatide, labs optional
8.8/10
Monthly
$199/mo
True Annual
$2,388/yr
Labs
✗ Extra
States
All 50
Pros
✓Fast approval process — under 24 hours
✓Compounded sema and tirzepatide available
✓Free shipping on all orders
Cons
✗Labs not included
✗Newer provider
Side-by-side comparison
| Feature | Sesame Care | DirectMeds |
|---|---|---|
| Monthly price | $16/mo | $199/mo |
| True annual cost | $192/yr | $2,388/yr |
| Labs included | ✗ No | ✗ No |
| Delivery options | oral, injection, topical | injection |
| Editorial score | 8.3/10 | 8.8/10 |
| Trustpilot | 4.5★ | 4.5★ |
| State availability | All 50 states | All 50 states |
Our verdict
DirectMeds (8.8/10) is our pick over Sesame Care (8.3/10) for most patients.
Sesame Care may be a better fit if you want more delivery options (oral, injection, topical). Both clinics require a prescription and blood work before starting treatment.
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Sesame Care vs Remedy Meds
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