GLP-1 / Weight Loss › Head-to-head comparison

DirectMeds vs Enhance MD

True annual cost, labs inclusion, delivery methods, and verified reviews compared. Updated March 2026.

★

Our pick: DirectMeds — 8.8/10 vs 8.7/10, higher rated

★ Our Pick

DirectMeds

Compounded GLP-1 from $199/mo — semaglutide and tirzepatide, labs optional

8.8/10

Monthly

$199/mo

True Annual

$2,388/yr

Labs

✗ Extra

States

All 50

Pros

✓Fast approval process — under 24 hours

✓Compounded sema and tirzepatide available

✓Free shipping on all orders

Cons

✗Labs not included

✗Newer provider

Enhance MD

GLP-1 & NAD+ from $115/mo — labs included, physician-led, all-inclusive pricing

8.7/10

Monthly

$115/mo

True Annual

$1,380/yr

Labs

✓ Included

States

Most states

Pros

✓Labs included in all plans — true all-in pricing

✓Physician-led with ongoing virtual care

✓NAD+, GLP-1, and GIP/GLP-1 (tirzepatide) all available

Cons

✗Not available in 11 states (AL, AR, GA, HI, LA, MS, MO, ND, SC, TN, WV)

✗GLP-1 focused — not a full mens health platform

Side-by-side comparison

Feature	DirectMeds	Enhance MD
Monthly price	$199/mo	$115/mo
True annual cost	$2,388/yr	$1,380/yr
Labs included	✗ No	✓ Yes
Delivery options	injection	injection
Editorial score	8.8/10	8.7/10
Trustpilot	4.5★	4.4★
State availability	All 50 states	38 US states (excl. AL, AR, GA, HI, LA, MS, MO, ND, SC, TN, WV)