GLP-1 / Weight Loss › Head-to-head comparison
DirectMeds vs Novi
True annual cost, labs inclusion, delivery methods, and verified reviews compared. Updated March 2026.
★
Our pick: DirectMeds — 8.8/10 vs 8.5/10, higher rated
★ Our Pick
DirectMeds
Compounded GLP-1 from $199/mo — semaglutide and tirzepatide, labs optional
8.8/10
Monthly
$199/mo
True Annual
$2,388/yr
Labs
✗ Extra
States
All 50
Pros
✓Fast approval process — under 24 hours
✓Compounded sema and tirzepatide available
✓Free shipping on all orders
Cons
✗Labs not included
✗Newer provider
VS
Novi
GLP-1 weight loss — $300 CPA | physician-supervised, compounded sema
8.5/10
Monthly
$179/mo
True Annual
$2,148/yr
Labs
✗ Extra
States
Most states
Pros
✓$300 CPA highest GLP-1 payout
✓Physician-supervised protocol
✓Compounded semaglutide
Cons
✗Newer provider
✗Limited public reviews
Side-by-side comparison
| Feature | DirectMeds | Novi |
|---|---|---|
| Monthly price | $199/mo | $179/mo |
| True annual cost | $2,388/yr | $2,148/yr |
| Labs included | ✗ No | ✗ No |
| Delivery options | injection | injection |
| Editorial score | 8.8/10 | 8.5/10 |
| Trustpilot | 4.5★ | 4.4★ |
| State availability | All 50 states | Most US states |
Our verdict
DirectMeds (8.8/10) is our pick over Novi (8.5/10) for most patients.
Novi may be a better fit if you prefer Novi's specific protocol approach. Both clinics require a prescription and blood work before starting treatment.
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