Best Telehealth Clinics in Missouri (2026)

Missouri's telehealth prescribing is governed by RSMo § 334.108, which requires a valid physician-patient relationship under RSMo § 191.1146 before prescribing any drug or controlled substance via telemedicine. The physician-patient relationship can be established through (1) an in-person encounter, (2) consultation with another physician who has an established relationship, or (3) a telemedicine encounter "if the standard of care does not require an in-person encounter." This third option creates a legal gray zone for controlled substances.

RSMo § 334.108 also prohibits prescribing "based solely on an internet request or an internet questionnaire." This means purely asynchronous or questionnaire-based prescribing models are illegal in Missouri. A live clinical interaction is required.

Missouri has unusually strict collaborative practice requirements for nurse practitioners under RSMo § 334.104. APRNs prescribing Schedule III through IV controlled substances must operate within 75-mile geographic proximity of their collaborating physician. Schedule III narcotic controlled substances are limited to a 120-hour supply without refill under APRN collaborative arrangements. Missouri is not a full practice authority state for NPs.

Missouri is an active IMLC member. The core telehealth framework (§§ 334.108, 191.1145-1146) predates COVID. Missouri did not pass a broad COVID telehealth permanency bill. The DEA waiver through December 2026 provides the federal basis for telehealth controlled substance prescribing.

Missouri has 6.2 million residents. Provider availability is reduced compared to other large states due to the standard-of-care ambiguity around telehealth controlled substance prescribing and the strict APRN requirements.

TRT Nation explicitly excludes Missouri (along with AL, AK, AR, and HI). The likely reason is RSMo § 334.108's ambiguity about whether telehealth alone satisfies the standard of care for initiating testosterone, combined with the APRN supervision requirements and the 120-hour controlled substance supply limit.

Providers that do serve Missouri for TRT include Maximus ($100/mo, all 50 states), Hone Health ($25/mo, all 50 states), and providers listing "Most US states" like BraverX ($129/mo), PeterMD ($99/mo), DudeMeds ($77/mo), and Titan Medical ($99/mo).

GLP-1 availability is good. Embody, SkinnyRx, DirectMeds, Zealthy, Remedy Meds, GobyMeds, Sesame Care, and other national providers serve Missouri. Missouri Medicaid covers GLP-1s for obesity as of August 2024.

Enhance MD excludes 11 states including MO. All HRT, hair loss, and ED providers with national coverage serve the state.

TRT pricing from available providers: DudeMeds $77/mo ($1,124/year), PeterMD $99/mo ($1,188/year), Maximus $100/mo ($1,300/year), BraverX $129/mo ($1,548/year). TRT Nation ($99/mo) does not serve Missouri.

GLP-1 ranges from $99/mo to $399/mo. Median is $179/mo. Missouri HealthNet (Medicaid) covers GLP-1 receptor agonists for obesity with prior authorization as of the PDL edit effective October 15, 2024.

Missouri does not tax prescription medications. The state sales tax is 4.225% (plus local) but Rx drugs are exempt.

HRT: Midi Health (insurance), PlushCare ($20/mo), Evernow ($35/mo). ED: Hims $17/mo to MEDVi $119/mo.

TRT (testosterone replacement therapy)

Missouri's standard-of-care test under RSMo § 191.1146 creates ambiguity for telehealth-only TRT initiation. TRT Nation excludes MO for this reason. Providers that do serve Missouri (Maximus, Hone, BraverX) are operating under the federal DEA waiver. The prohibition on questionnaire-only prescribing (§ 334.108) means a live clinical interaction is required. The APRN 120-hour supply limit affects nurse practitioner-prescribed testosterone.

GLP-1 weight loss

No state-specific GLP-1 restrictions beyond the general prescribing rules. Missouri HealthNet covers GLP-1s for obesity with PA. Federal FDA compounding rules apply.

HRT (hormone replacement therapy)

HRT follows standard federal prescribing rules in Missouri. No additional state restrictions apply.

Hair loss

Hair loss treatment follows standard federal prescribing rules in Missouri. No additional state restrictions apply.

ED (erectile dysfunction)

ED treatment follows standard federal prescribing rules in Missouri. No additional state restrictions apply.

Peptides

Peptide therapy follows standard federal rules. The RSMo § 334.108 standard-of-care test applies to all telehealth prescriptions. Non-controlled peptides have fewer barriers.