GLP-1 / Weight Loss › Head-to-head comparison
DirectMeds vs TRT Nation
True annual cost, labs inclusion, delivery methods, and verified reviews compared. Updated March 2026.
★
Our pick: TRT Nation — 9.2/10 vs 8.8/10, $942/yr cheaper
DirectMeds
Compounded GLP-1 from $199/mo — semaglutide and tirzepatide, labs optional
8.8/10
Monthly
$199/mo
True Annual
$2,388/yr
Labs
✗ Extra
States
All 50
Pros
✓Fast approval process — under 24 hours
✓Compounded sema and tirzepatide available
✓Free shipping on all orders
Cons
✗Labs not included
✗Newer provider
VS
★ Our Pick
TRT Nation
$99/mo flat — unlimited consultations, no contracts
9.2/10
Monthly
$99/mo
True Annual
$1,446/yr
Labs
✗ Extra
States
Most states
Pros
✓Lowest all-in price at $99/mo
✓Unlimited free consultations
✓HCG available
Cons
✗Labs not included
✗Not available in 5 states
Side-by-side comparison
| Feature | DirectMeds | TRT Nation |
|---|---|---|
| Monthly price | $199/mo | $99/mo |
| True annual cost | $2,388/yr | $1,446/yr |
| Labs included | ✗ No | ✗ No |
| Delivery options | injection | injection, cream |
| Editorial score | 8.8/10 | 9.2/10 |
| Trustpilot | 4.5★ | 4.5★ |
| State availability | All 50 states | 45 states (not AL, AK, AR, MO, HI) |
Our verdict
TRT Nation (9.2/10) is our pick over DirectMeds (8.8/10) for most patients. At $1,446/yr vs $2,388/yr, TRT Nation saves you $942 per year.
DirectMeds may be a better fit if you prefer DirectMeds's specific protocol approach. Both clinics require a prescription and blood work before starting treatment.
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