GLP-1 / Weight Loss › Head-to-head comparison
DirectMeds vs Male Excel
True annual cost, labs inclusion, delivery methods, and verified reviews compared. Updated March 2026.
★
Our pick: Male Excel — 9.2/10 vs 8.8/10, $1,000/yr cheaper
DirectMeds
Compounded GLP-1 from $199/mo — semaglutide and tirzepatide, labs optional
8.8/10
Monthly
$199/mo
True Annual
$2,388/yr
Labs
✗ Extra
States
All 50
Pros
✓Fast approval process — under 24 hours
✓Compounded sema and tirzepatide available
✓Free shipping on all orders
Cons
✗Labs not included
✗Newer provider
VS
★ Our Pick
Male Excel
Excel Advantage Program — personalized 60-day check-ins
9.2/10
Monthly
$99/mo
True Annual
$1,388/yr
Labs
✗ Extra
States
Most states
Pros
✓60-day health assessments included
✓1-on-1 support with personal medical provider
✓Money-back guarantee
Cons
✗Labs not included in base price
✗No HCG
Side-by-side comparison
| Feature | DirectMeds | Male Excel |
|---|---|---|
| Monthly price | $199/mo | $99/mo |
| True annual cost | $2,388/yr | $1,388/yr |
| Labs included | ✗ No | ✗ No |
| Delivery options | injection | injection, cream |
| Editorial score | 8.8/10 | 9.2/10 |
| Trustpilot | 4.5★ | 4.5★ |
| State availability | All 50 states | Most US states |
Our verdict
Male Excel (9.2/10) is our pick over DirectMeds (8.8/10) for most patients. At $1,388/yr vs $2,388/yr, Male Excel saves you $1,000 per year.
DirectMeds may be a better fit if you prefer DirectMeds's specific protocol approach. Both clinics require a prescription and blood work before starting treatment.
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