Peptides › Head-to-head comparison
Defy Medical vs Enhance MD
True annual cost, labs inclusion, delivery methods, and verified reviews compared. Updated March 2026.
★
Our pick: Defy Medical — 8.8/10 vs 8.7/10, higher rated
★ Our Pick
Defy Medical
$200-$250/mo — most comprehensive peptide clinic
8.8/10
Monthly
$200/mo
True Annual
$2,800/yr
Labs
✓ Included
States
Most states
Pros
✓Widest peptide selection
✓Experienced physicians
✓Labs included
Cons
✗Most expensive option
✗Not all states
VS
Enhance MD
GLP-1 & NAD+ from $115/mo — labs included, physician-led, all-inclusive pricing
8.7/10
Monthly
$115/mo
True Annual
$1,380/yr
Labs
✓ Included
States
Most states
Pros
✓Labs included in all plans — true all-in pricing
✓Physician-led with ongoing virtual care
✓NAD+, GLP-1, and GIP/GLP-1 (tirzepatide) all available
Cons
✗Not available in 11 states (AL, AR, GA, HI, LA, MS, MO, ND, SC, TN, WV)
✗GLP-1 focused — not a full mens health platform
Side-by-side comparison
| Feature | Defy Medical | Enhance MD |
|---|---|---|
| Monthly price | $200/mo | $115/mo |
| True annual cost | $2,800/yr | $1,380/yr |
| Labs included | ✓ Yes | ✓ Yes |
| Delivery options | injection | injection |
| Editorial score | 8.8/10 | 8.7/10 |
| Trustpilot | 4.6★ | 4.4★ |
| State availability | Most US states | 38 US states (excl. AL, AR, GA, HI, LA, MS, MO, ND, SC, TN, WV) |
Our verdict
Defy Medical (8.8/10) is our pick over Enhance MD (8.7/10) for most patients.
Enhance MD may be a better fit if you prefer Enhance MD's specific protocol approach. Both clinics require a prescription and blood work before starting treatment.
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